Health & Wellness

According to science, how selenium can extend lifespan

Selenium, a powerful mineral that helps regulate metabolism and thyroid function, can also increase longevity. Researchers found that this important nutrient can prevent obesity and improve metabolic processes in mice.

The study was published by Weil Cornell Medicine and the Orientreich Foundation for the Advancement of Science Life on March 30, 2021.

Scientists say the findings may lead to treatments that simulate the anti-aging effects associated with diet-restriction. Best of all, people can continue to eat their regular diet during treatment.

The team said that some diets have been shown to increase lifespan while promoting health. Many organisms, including non-human mammals, have responded positively to the restriction of methionine, an amino acid, in their diet. Recent studies have suggested that similar effects seen in other animals would apply to humans. A vegetarian diet automatically restricts the consumption of methionine, but such a limited diet will not be practical for everyone.

In the current study, the research team from OFAS in Cold Spring, New York attempted to develop a separate intervention. They wanted to reiterate the effects of the methionine ban, while still allowing people to eat a regular diet.

In developing this treatment, an important fact to remember is that methionine restriction reduces IGF-1, an energy-regulating hormone. If the intervention developed by them can cause a similar decrease in IGF-1, it may also benefit lifespan. Prior studies have found that selenium supplementation reduces the amount of circulating IGF-1 in mice, which shows promise for this research.

Studies have shown that selenium can increase longevity and prevent obesity.

First, the team wanted to test whether supplementation with selenium would prevent obesity in the same manner as the methionine restriction. To do this, they gave young male and older female mice three different high-fat diets. The diet of the control group contained moderate amounts of methionine, while the other group ate a methionine-restricted diet. The last group followed a diet with moderate amounts of methionine with selenium supplementation.

The authors discovered startling results in male and female mice of all ages in the control and methionine-restricted groups. They found that selenium supplements offered complete protection against obesity and accumulation of fat in mice.

They then studied how the three diets triggered physiological changes, which usually accompany methionine restriction. To accomplish this, they measured the levels of four metabolic markers in blood samples from mice. As they expected, the team dramatically reduced IGF-1 levels in male and female mice alike. In addition, they found that the hormone leptin, which regulates appetite and energy expenditure, was reduced.

Understanding the outcome

These results suggest that selenium supplementation reproduces most of the effects of methionine restriction. Furthermore, this means that treatment can positively affect lifespan.

To better understand the benefits of selenium supplementation, the team tried a yeast experiment. They measured two of the most common markers of lifespan in yeast: chronological life span and replicative life span. The former suggests that chronically inactive yeast remains viable. The latter shows how often a yeast cell can produce new progeny.

In previous studies, the team found that methionine restriction caused a longer chronological life span in yeast. In this study, they wanted to find out whether selenium supplementation would have the same effect. The experiment showed that the yeast was given Selenium supplementation had a 62% longer chronological life span (from 13 days to 21 days). Furthermore, their replication increased to nine generations with life span control.

It has been proven that feeding yeast selenium supplements provides the benefits of longevity, observed in many cell aging trials.

“A major goal of aging research is to identify simple interventions that promote human health,” said senior author Jay Johnson, OFAS senior scientist. “Here we present evidence that short-term administration of organic or inorganic sources of selenium provides several health benefits to mice, the most notable of which is the prevention of diet-induced obesity. In the long term, we expect that supplementation with these compounds will also prevent age-related disease and extend the overall survival of mice. We hope that many of the benefits seen for mice will also be for humans. ”

Other benefits of selenium

Apart from improving lifespan and preventing obesity, selenium offers many other benefits.

  • The risk of some cancers may be reduced. a Meta-analysis 69 studies, including more than 350 people, found that high selenium intake reduced the risk of some cancers. Breast, lung, colon, and prostate cancers were responding positively to selenium.
  • Prevents heart disease. One Analysis 25 observational studies showed that the risk of heart disease was reduced by about 25% when selenium levels increased by 50%.
  • Enrichs cognitive health. One Study It was found that the intake of selenium in supplements or foods improved the memory of Alzheimer’s patients.

Best Sources Of Selenium:

  • Oyster: 238% DV in 3 ounces (85 grams)
  • Brazilian Nut: 174% DV in one nut (5 grams)
  • Halibut: 171% (159 grams) of DV in 6 ounces
  • Yellowfin Tuna: 167% DV in 3 ounces (85 grams)
  • Eggs: 56% DV in 2 large eggs (100 g)
  • Sardines: 48% DV (48 g) in 4 sardines.
  • Sunflower seeds: 27% of DV in 1 ounce (28 grams)
  • Chicken Breast: 12% of DV in 4 slices (84 grams)
  • Shiatek Mushrooms: 10% DV in 1 cup (97 grams)

Final Thoughts: A study found that eating selenium can prolong life

If you do not eat enough selenium, you may want to add something to your diet to enjoy a longer life. Just one brazil nut has more than RDI Selenium, for example, provides an easy source for the mineral. Seafood, eggs, and some types of meat also contain a lot of selenium. In addition to extending lifespan, this important mineral aids in thyroid function and may relieve obesity.

While we require very little selenium to survive, it can help us enjoy our time on Earth.

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